There are a variety of options for treating osteoarthritis in a knee joint. Generally, OTC medications, such as acetaminophen and ibuprofen, and first-line treatments are normally used. Additional treatments may include prescription medications, corticosteroid injections, viscosupplementation, and biologic-type injections. Total knee arthroplasty (knee replacement) is the final option for advanced osteoarthritis that fails to respond to other treatments. Get in touch with us to learn more from an orthopedic physician at Nolo Ortho.